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Chem Impex International
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Eppendorf AG
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Cayman Chemical
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Image Search Results
Journal: Journal of Biomolecular Structure & Dynamics
Article Title: Emerging role of artificial intelligence in therapeutics for COVID-19: a systematic review
doi: 10.1080/07391102.2020.1855250
Figure Lengend Snippet: Summary of artificial intelligence-based studies for therapeutics of COVID-19.
Article Snippet: Likewise, DFCNN was also applied to screen three other
Techniques: Binding Assay, Expressing, Activity Assay, Infection, Sequencing, In Silico, In Vitro, Stability Assay, High Throughput Screening Assay
Journal: Journal of Biomolecular Structure & Dynamics
Article Title: Emerging role of artificial intelligence in therapeutics for COVID-19: a systematic review
doi: 10.1080/07391102.2020.1855250
Figure Lengend Snippet: Target-wise categorization of identified drugs through AI for COVID-19 therapeutics.
Article Snippet: Likewise, DFCNN was also applied to screen three other
Techniques:
Journal: Slas Discovery
Article Title: High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
doi: 10.1177/2472555220963667
Figure Lengend Snippet: Papain-like protease (PLpro) ReFRAME primary high-throughput screening (HTS) assay results. Graphed is a single-point scatterplot of all 13,104 compounds tested. Each dot graphed represents the activity result of a well containing test compound (black dots) or controls (red, violet, and green dots). The gap in the sample index (well number) is due to test wells that weren’t inclusive of compounds, and hence no data are plotted and available.
Article Snippet: Based on the protein structure of
Techniques: High Throughput Screening Assay, HTS Assay, Activity Assay
Journal: Slas Discovery
Article Title: High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
doi: 10.1177/2472555220963667
Figure Lengend Snippet: Confirmation of ReFRAME hit compounds in luciferase assay. Luciferase-based protease assays were performed in 96-well plates, as described in . Cells were transfected in 6-well plates and then reseeded into 96-well plates containing compounds at 20,000 cells per well for 4 h post transfection. ( A ) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro) and SARS-CoV-1 PLpro activity in the presence of compounds at threefold dilutions starting at a maximum concentration of 20 µM. ( B ) Activity of indicated proteases represented as relative to protease without compound treatment. Compounds were added at threefold dilutions starting at 10 µM.
Article Snippet: Based on the protein structure of
Techniques: Luciferase, Transfection, Activity Assay, Concentration Assay